In this study we compare the biomechanical push- and pullout forces of Magnesium (RemeOs™ ZX00) bone-screws to bone screws of different materials, but similar dimensions. Testing was performed at the time points 0, 3, 6, 12, 16, and 26 weeks. The commercially available comparator articles are cannulated, PLGA (ActivaScrew™) and Titanium (Synthes® Titanium) screws. By using not only pullout, but also pushout testing and normalizing the forces to the amount of threads in contact, we eliminate some of the common complications found in in vivo tests. The ZX00 test object yielded normalized push- and pullout forces higher than the PLGA material and lower than the titanium screws at all tested timepoints. Our results suggest that ZX00 screws are a promising bioresorbable alternative that keeps up with other already marked-approved materials in terms of biomechanical strength.

Postoperative cardiac arrhythmias are routinely treated with temporary epicardial pacing wires (TEPW) made of stainless steel that are implanted at the time of heart surgery. However, both manually extracting and leaving steel TEPW in the body may cause rare but potentially serious complications. We investigate the novel approach of using bioresorbable molybdenum (Mo) TEPW that can remain in the body and are fully resorbed after a defined time. Degradation, functionality, and bio-compatibility in-vitro were already shown in the first part of the study. In the second part of our study, in-vivo performance of the Mo TEPW is investigated.

The desire to improve patient outcome in Percutaneous coronary intervention (PCI), has continued to drive the development of resorbable Magnesium scaffold (RMS). Biotronik has played a leading role in pioneering the development of a competitive RMS for coronary vascular intervention. This work reviews the outcome of the clinical trials carried out on the first, second and third generation RMS in the past, and relates it with the scaffold base material used.