Vue d'ensemble de la session |
| Monday, July 22 |
Chairs: Dr. Véronique Witko-Sarsat, Dr. Mustapha Si-Tahar
During this symposium, the speakers will highlight recent advances in strategies to understand and regulate lung inflammatory processes. Topics include the "role of CFTR in neutrophil functions in cystic fibrosis" and the "neonatal cross-talk of alveolar macrophages and neutrophils regulating lung inflammation" offering insights into potential therapeutic breakthroughs. The symposium will also cover the "metabolic control of virus-induced lung inflammation" and "specialized pro-resolving mediators in respiratory diseases," presenting innovative approaches to manage lung inflammation. By uncovering these new control points, the speakers aim to redefine current approaches, opening avenues for breakthroughs in therapeutic interventions.
Effect of CFTR modulators on lung inflammation and neutrophil functions in cystic fibrosis
Dr. Véronique Witko-Sarsat, Institut Cochin, France
Neonatal cross-talk of alveolar macrophages and neutrophils regulate lung inflammation
Dr. Erwan Pernet, Université du Québec à Trois-Rivières, Canada
Metabolic control of virus-induced lung inflammation
Dr. Mustapha Si-Tahar, Inserm-CEPR, France
Specialized pro-resolving mediators in respiratory diseases
Pr. Bruce Levy, Brigham and Womens Hospital, USA
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Effect of CFTR modulators on lung inflammation and neutrophil functions in cystic fibrosis
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Neonatal cross-talk of alveolar macrophages and neutrophils regulate lung inflammation
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Metabolic control of virus-induced lung inflammation
* Mustapha Si-Tahar, Research Center for Respiratory Diseases, France Metabolism and immunity, historically siloed research domains, have recently converged under the concept of immunometabolism. In the context of influenza virus infection, we have shown that the lung mucosa undergoes metabolic reprogramming, leading to the accumulation of specific metabolites known as metabokines. We revealed the dual functionality of certain metabokines as they regulate host immune cell responses through the modulation of inflammatory signaling and the induction of post-translational protein modifications. Simultaneously, these compounds directly or indirectly disrupt influenza virus replication. These major findings offer significant potential for innovative treatments targeting inflammation and viruses. |
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Specialized pro-resolving mediators in respiratory diseases
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